PM465. Frontal-Striatal Exploratory Reasoning and Effects of Social Stress and Idea Generation

s | 69 Abstract Introduction: Patients with schizophrenia show deficits symptoms as anhedonia. This study was designed to find neural correlates of anhedonia during shopping behavior and compared the results between healthy controls and patients with schizophrenia. We hypothesized that anhedonia would influence the shopping behavior as negative way in schizophrenia. Methods: 20 patients with schizophrenia and 20 healthy controls participated in the study. Participants were engaged in a ‘shopping task’ during functional magnetic resonance imaging (fMRI) scanning. Patients were administered Intrinsic Motivation and Extrinsic Motivation scale (IM & EM) and anhedonia scale. Pearson correlations of regional activities with behavioral responses such as score preference and clinical scales. Results: Patients preferred their own appearance wearing the cloth and that made them finally purchase the product. However, decreased activity of right posterior cingulate cortex (PCC) was found in the ‘self-appearance wearing the product’ condition in patients. Increment in activation of the lingual gyrus was correlated with lower score of the anhedonia scale. Conclusions: This study investigated neural correlates of shopping behavior affected by anhedonia in controls and patients with schizophrenia. Interestingly, patients preferred more their new look appearance than controls and purchased the products. This shopping behavior was also negatively correlated with severity of anhedonia. As we hypothesized, patients with schizophrenia showed careless shopping behavior and it was related to anhedonia.Introduction: Patients with schizophrenia show deficits symptoms as anhedonia. This study was designed to find neural correlates of anhedonia during shopping behavior and compared the results between healthy controls and patients with schizophrenia. We hypothesized that anhedonia would influence the shopping behavior as negative way in schizophrenia. Methods: 20 patients with schizophrenia and 20 healthy controls participated in the study. Participants were engaged in a ‘shopping task’ during functional magnetic resonance imaging (fMRI) scanning. Patients were administered Intrinsic Motivation and Extrinsic Motivation scale (IM & EM) and anhedonia scale. Pearson correlations of regional activities with behavioral responses such as score preference and clinical scales. Results: Patients preferred their own appearance wearing the cloth and that made them finally purchase the product. However, decreased activity of right posterior cingulate cortex (PCC) was found in the ‘self-appearance wearing the product’ condition in patients. Increment in activation of the lingual gyrus was correlated with lower score of the anhedonia scale. Conclusions: This study investigated neural correlates of shopping behavior affected by anhedonia in controls and patients with schizophrenia. Interestingly, patients preferred more their new look appearance than controls and purchased the products. This shopping behavior was also negatively correlated with severity of anhedonia. As we hypothesized, patients with schizophrenia showed careless shopping behavior and it was related to anhedonia. PM465 Frontal-Striatal Exploratory Reasoning and Effects of Social Stress and Idea Generation Amelia KOH*1, Dilip KUMAR*1, Violet CHUA2, Yih Yian SITOH2, Hao Yang TAN1 *equal contribution 1Nanyang Technological University Lee Kong Chian School of Medicine, Singapore, 2National Neuroscience Institute Tan Tock Seng Hospital, Singapore Abstract Background: Neuropsychiatric disorders like schizophrenia and bipolar disorder often have onset in late adolescence or early adulthood periods associated with increased prefrontalstriatal reactivity to social stress. Exploratory reasoning, ideasBackground: Neuropsychiatric disorders like schizophrenia and bipolar disorder often have onset in late adolescence or early adulthood periods associated with increased prefrontalstriatal reactivity to social stress. Exploratory reasoning, ideas generation and creativity, may also be sensitive to social competitive stress prevalent in urban societies. Further, creative processes have been associated with the genetics of neuropsychiatric disease (Power et al 2015). However, little is understood about the neural correlates of these processes. In particular, how prefrontal-striatal engagement in probabilistic exploratory reasoning might be influenced by social stress, and their relationship with creative processes. Methods: We studied 21 young adults in a 3T-MRI. The fMRI paradigm engaged events where subjects explored whether a hidden number was higher or lower than a presented number, or exploited knowledge of the hidden number. Trials were performed with or without induced social-competitive stress featuring a competitor doing better at the same task. Outside of the scanner, subjects also generated ideas about uses for a picture of a bottle and a paper clip, whose score was examined with the imaging data. Results: Social stress was associated with faster and more risky exploratory responses (p<0.01), although performance accuracy per se was not significantly affected. Idea generation did not correlate with exploratory reaction time or risks taken in this sample. Prefrontal-striatal function was robustly engaged during exploratory reasoning (p<0.05 FWE corrected), but was reduced by induced social stress (p<0.001 uncorrected). Higher scores on idea generation appeared to mitigate the prefrontalstriatal effects of induced social stress on exploratory reasoning (p<0.001 uncorrected). Conclusions: Prefrontal-striatal functions engaged by young adults in exploratory reasoning appear to be affected by induced social stress to varying extents, modulated by idea generation and creative processes as potential protective factors. Individual variation and neuropsychiatric risk mechanisms may relate to exploratory information processing and creative abilities through interactions with the neural responses to social stress. PM466 Neuroanatomical implications of concomitant mood disorders in subjects at clinical high risk for psychosis Yoo Bin Kwak1,, Tae Yong Lee2, Kang Ik Cho1, Minah Kim3, Sung Nyun Kim3, Jun Soo Kwon1,3,4* 1 Department of Brain and Cognitive Sciences, Seoul National University College of of Natural Sciences, Seoul, Republic of Korea 2 Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea 3 Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea 4 Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea Abstract Background: Mood disorders are present in about 40% of individuals at clinical high risk (CHR) for psychosis. Such high prevalence of symptomatic concomitants raises the need to address and assess the contemporary assumption that characterizes CHR states as being subserved by common neuroanatomical alterations. The present study investigated the relevance of mood symptoms on the CHR neuroanatomy and symptomatology. Methods: Magnetic resonance images from a sample of 44 CHR individuals with mood disorders (CHR-M), 30 CHR individuals without moor disorders (CHR-NM), and 34 healthy control subjects (HC) were analyzed. Measures of cortical thickness (CT) were extracted using a surface-based morphometry analysis. Ratings of Structured Interview for Psychosis Risk Syndromes (SIPS) sub-scales and global functioning were also analyzedBackground: Mood disorders are present in about 40% of individuals at clinical high risk (CHR) for psychosis. Such high prevalence of symptomatic concomitants raises the need to address and assess the contemporary assumption that characterizes CHR states as being subserved by common neuroanatomical alterations. The present study investigated the relevance of mood symptoms on the CHR neuroanatomy and symptomatology. Methods: Magnetic resonance images from a sample of 44 CHR individuals with mood disorders (CHR-M), 30 CHR individuals without moor disorders (CHR-NM), and 34 healthy control subjects (HC) were analyzed. Measures of cortical thickness (CT) were extracted using a surface-based morphometry analysis. Ratings of Structured Interview for Psychosis Risk Syndromes (SIPS) sub-scales and global functioning were also analyzed between the CHR-M and CHR-NM subgroups. Associations between brain structural alterations and clinical measures were assessed by calculating Pearson’s correlation coefficients. Results: Compared with HC, CHR group as a whole showed widespread cortical thinning and GMV reductions, along with ventricular enlargements. The subgroups of CHR-M and CHR-NM did not differ in measures of CT but did so in those of GMV: GMV reductions in temporo-parieto-occipital regions, along with more pronounced ventricular enlargements, were more pronounced in CHR_NM, whereas reductions in frontal regions were more pronounced in CHR-M. The two subgroups also differed in psychotic symptoms and global functioning, with significantly worse negative psychopathology and functional impairments found in CHR-M. However, no significant correlations between brain structural alterations and clinical measures were found after correction for multiple comparisons. Conclusion: The different patterns of brain structural alterations and clinical ratings found between the CHR-NM and CHR-M subgroups seem to suggest the impact of concomitant mood pathologies in CHR. The present study may contribute to